When the researchers exposed the week-old mice to a nitrogen and carbon dioxide gas mixture to mimic asphyxia, the animals gasped less for air and were more likely to die than unaltered mice.
This same technique can be used safely on infants during inconsolable crying, to see if the activity occurs where the model predicts.
“We do hope that wherever we may be wrong or incomplete, these ideas will refresh and stimulate an entirely new direction of research into what makes us humans susceptible to these seemingly very different phenomena, and colic,” Mc Kenna says, “two areas where new ideas are always both welcomed and needed.” Wendy Middlemiss of the University of North Texas and Mary S.
UNLABELLED Despite the large reduction in SIDS mortality, which occurred in the early 1990s following the ' Back to Sleep' campaigns, SIDS remains the leading cause of death in the postneonatal age group.
This paper describes the position in the 1980s, the contribution of the New Zealand Cot Death Study, what should be recommended and the current research priorities. Application of what we currently know could eliminate SIDS.
If the weakened gasping seen in the neurologically impaired mice turns out to be identifiable in human babies with a higher risk of SIDS, it could give doctors a potential diagnostic criterion, the authors note in the paper.
Ethan Eade Phd Thesis - Sids Research Paper
And the results also could offer a mechanistic explanation for abnormalities seen in the serotonin neurons of babies who died of the disorder.
“Rather than colic reflecting digestive pain, as has often been assumed, we propose that it could be fear as the infant does more of what it is trying to reverse — that is, cry — becoming a victim of its own immature neural structures that are firing simultaneously and excessively.” The research team emphasizes that the model presented in their paper has yet to be tested, but observes that several lead researchers have taken note.
The first step in testing the model is by using magnetic resonance imaging to look at the neural structures involved when sleeping infants experience an apnea followed by a cortex-induced arousal.
He also has an appointment as an Adjunct Clinical Assistant Professor in the Departments of Pediatrics, Child Psychiatry, and Human Behavior at the University of California, Irvine, School of Medicine.
His primary research interests and many of his publications concern aspects of primate parenting and infant development among both human and nonhuman primates.