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To gain further insight into the phenotype of HMS/EDS-HT and its mechanisms, clearer descriptions of these populations should be made available.Future research and clinical care should revise and create consensus on the diagnostic criteria for HMS/EDS-HT (Solution 1), account for clinical heterogeneity by the classification of subtypes within the HMS/EDS-HT spectrum (Solution 2), and create a clinical core set (Solution 3).
NOTE: Results of this study will not be disclosed to subjects.
Medical records from other institutions and clinical notes for visits in Dr.
Both physicians combined the pertinent features of the syndrome and accurately delineated the phenotypic features of this group of inherited disorders.
The name, Ehlers-Danlos syndrome, was coined in 1936.
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Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site.People with lax joints and multiple scars were first described in the medical writings of Hippocrates, dating back to 400 BCE. His work reports the first detailed clinical description of EDS.The syndrome derives its name from additional clinical case reports presented by 2 physicians: Edvard Ehlers, a Danish dermatologist, in 1901, and Henri-Alexandre Danlos, a French physician with expertise in chemistry of skin disorders, in 1908.Depending on the type, EDS can be diagnosed through laboratory studies or clinical examination.Once the syndrome has been diagnosed, preventative measures should be taken. Tschernogobow, a Russian dermatologist, presented 2 case studies of patients to the Moscow Venereology and Dermatology Society who had marked loose fragile skin, and hypermobile large joints.Holick's clinic will be reviewed to obtain the following information: previous diagnosis at other institutions, age, clinical signs and symptoms of EDS, Joints Hypermobility Syndrome (JHS), and other metabolic or genetic disorders and laboratory results, radiology reports and images, and genetic testing that supports EDS diagnoses. Accepted for publication 11 June 2015 Published 20 August 2015 Volume 2015:8 Pages 591—601 DOI https://doi.org/10.2147/JPR.However, within the Ehlers–Danlos spectrum, a similar subcategory of patients having similar clinical features as HMS but lacking a specific genetic profile was identified: Ehlers–Danlos syndrome hypermobility type (EDS-HT).Researchers and clinicians have struggled for decades with the highly diverse clinical presentation within the HMS and EDS-HT phenotypes (Challenge 1) and the lack of understanding of the pathological mechanisms that underlie the development of pain and its persistence (Challenge 2).Keywords: chronic musculoskeletal pain, generalized joint hypermobility, hypermobility syndrome, Ehlers–Danlos hypermobility type This work is published and licensed by Dove Medical Press Limited.The full terms of this license are available at https:// incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.